Expression of Kallikrein-Related Peptidases (KLKs) in Adenoid Cystic Carcinoma
نویسندگان
چکیده
..................................................................................................................................... ii Dedication ................................................................................................................................ iii Acknowledgments ................................................................................................................. iv Table of
منابع مشابه
Kallikrein-related peptidases (KLKs) in gastrointestinal cancer: mechanistic and clinical aspects.
The human tissue kallikrein (KLK1) and kallikrein-related peptidases (KLKs) are secreted serine proteases with diverse expression patterns and physiological roles in different systems, including the digestive system. The aberrant expression of KLKs in gastrointestinal malignancies as well as their implication in carcinogenesis including cell growth regulation, angiogenesis, invasion, and metast...
متن کاملKallikrein-Related Peptidases in Prostate Cancer: From Molecular Function to Clinical Application
Prostate cancer is a leading contributor to male cancer-related deaths worldwide. Kallikrein-related peptidases (KLKs) are serine proteases that exhibit deregulated expression in prostate cancer, with KLK3, or prostate specific antigen (PSA), being the widely-employed clinical biomarker for prostate cancer. Other KLKs, such as KLK2, show promise as prostate cancer biomarkers and, additionally, ...
متن کاملKallikrein-related peptidases (KLKs): a gene family of novel cancer biomarkers.
Early diagnosis of cancer and early detection of relapse following surgery are critical for the effective treatment of the disease and for a positive clinical outcome. Identification of novel diagnostic, prognostic and predictive biomarkers will contribute utmost to clinical decision-making. The human tissue kallikrein and kallikrein-related peptidases (KLKs), encoded by the largest contiguous ...
متن کاملKallikrein-related peptidases in prostate, breast, and ovarian cancers: from pathobiology to clinical relevance.
Tissue kallikrein (KLK1) and kallikrein-related peptidases (KLK2-15) comprise a family of 15 highly conserved secreted serine proteases with similar structural characteristics and a wide spectrum of functional properties. Both gene expression and protein activity of KLKs are rigorously controlled at various levels via diverse mechanisms, including extensive steroid hormone regulation, to exert ...
متن کاملFunctional proteomics of kallikrein-related peptidases in ovarian cancer ascites fluid.
Kallikrein-related peptidases (KLKs) are secreted serine proteinases with trypsin or chymotrypsin-like activity. Several family members, such as KLKs 6 and 10, are potential ovarian cancer biomarkers. Recently, using a newly developed assay for active KLK6, we found that only a very small proportion of immunoreactive KLK6 in tumor-derived clinical samples (malignant ascites fluid), in cerebrosp...
متن کامل